Misaki has light blonde hair and hazel-colored eyes. Her face seems to look annoyed most of the time, especially when she feels her pride is at stake. She is seen in a white shirt with red tie above it, the standard uniform at the Elementary school they attend.
Misaki is Hanako's classmate, who sees her as a rival but she is completely unrivaled. She often tries to outshine Hanako which usually results in her embarrassing herself. Even when Hanako is trying to help Misaki, its rather hard for the latter to let her pride go and accept. This is seen when Hanako wanted to walk under an umbrella with Misaki so neither get wet. When asked by Sakurako if she was Hanako's friend, Misaki outright denied it, saying she was her rival.
Ironically, Misaki gets along quite well with Sakurako (who the latter mistaken for a dog at first), both viewing their friends (Hanako and Himawari respectfully) as their rivals and Sakurako sees her younger self in Misaki.
- YuruYuri Nachuyachumi!+ (Cameo)
- Chapter 9
- Chapter 15
- Chapter 23
- Chapter 28
- Chapter 29
- Chapter 34
- Chapter 35
- Chapter 39
- Chapter 41
- Chapter 49
- Chapter 51
- Both her surname and given name end with "Saki".
- She can eat vegetables if they are in a drink form.
- It is revealed her mother styles her hair everyday.
- It is implied she shares a room with a sibling as she tells her mother she needs her own room after she invites Hanako and her friends over. 
- ↑ Chapter 51
|Ōmuro family||Sakurako Ōmuro • Hanako Ōmuro • Nadeshiko Ōmuro|
|Supporting characters||Himawari Furutani • Kaede Furutani • Mirai Sōma • Kokoro Ogawa • Ai Miwa • Megumi Sonokawa • Miho Yaeno • Misaki Takasaki • Ayano Sugiura • Chinatsu Yoshikawa • Kyōko Toshinō • Yui Funami|